1.1: isopropyl alcohol / 50 h / 4 - 25 °C 2.1: sodium hydroxide / water / 4 - 25 °C / pH 10 - 12 3.1: 2-methyl tetrahydrofuran / 10 - 35 °C / Inert atmosphere 3.2: 4 °C 4.1: trifluoroacetic anhydride / 2-methyl tetrahydrofuran / 35 - 45 °C 4.2: 20 - 35 °C / 2250.23 - 4500.45 Torr / Inert atmosphere 4.3: pH 10 - 12 5.1: formic acid / 10 - 95 °C 5.2: 20 - 25 °C / pH 9 - 10 5.3: 20 - 25 °C 6.1: methanesulfonic acid; dl-methionine / 75 - 80 °C 6.2: 15 - 50 °C / pH 10 - 11 View Scheme

hydrogenchloride in water; acetonitrile T=10 - 65°C; Mannich Aminomethylation;