3,5-二羟基苯基乙酸甲酯合成路线 （共 23 条）
反应条件
thionyl chloride T=20°C;
参考文献
IRM LLC
Patent: WO2007/56497 A1, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/056497 A1
反应条件
hydrogenchloride 16.5 h;
参考文献
Meltzer, Peter C.; Dalzell, Haldean C.; Razdan, Raj K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2825 - 2829
反应条件
1: SOCl2 / diethyl ether 2: ethanol 3: HI, AcOH 4: HCl View Scheme
参考文献
Archiv der Pharmazie, , vol. 305, # 2 p. 124 - 134
反应条件
1: ethanol 2: HI, AcOH 3: HCl View Scheme
参考文献
Archiv der Pharmazie, , vol. 305, # 2 p. 124 - 134
反应条件
1: LiAlH4 / diethyl ether 2: SOCl2 / diethyl ether 3: ethanol 4: HI, AcOH 5: HCl View Scheme
参考文献
Archiv der Pharmazie, , vol. 305, # 2 p. 124 - 134
反应条件
1: K2CO3 / acetone 2: LiAlH4 / diethyl ether 3: SOCl2 / diethyl ether 4: ethanol 5: HI, AcOH 6: HCl View Scheme
参考文献
Archiv der Pharmazie, , vol. 305, # 2 p. 124 - 134
反应条件
1: 95 percent / K2CO3 / acetone / 4.5 h / Heating 2: 97 percent / Red-al / toluene / 4 h / Heating 3: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C 4: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 5: 97 percent / KOH / ethanol / 18 h / Heating 6: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
反应条件
1: 97 percent / Red-al / toluene / 4 h / Heating 2: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C 3: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 4: 97 percent / KOH / ethanol / 18 h / Heating 5: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
反应条件
1: 100 percent / HCl / 5 h / Heating 2: 95 percent / K2CO3 / acetone / 4.5 h / Heating 3: 97 percent / Red-al / toluene / 4 h / Heating 4: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C 5: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 6: 97 percent / KOH / ethanol / 18 h / Heating 7: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
反应条件
1: 97 percent / Et3N / CH2Cl2 / 1.75 h / 0 °C 2: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 3: 97 percent / KOH / ethanol / 18 h / Heating 4: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
