3,5-二羟基苯基乙酸甲酯合成路线 （共 23 条）
反应条件
1: 97 percent / KOH / ethanol / 18 h / Heating 2: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
反应条件
1: 93 percent / 2-methoxy-ethanol / 17 h / 24 °C 2: 97 percent / KOH / ethanol / 18 h / Heating 3: 96 percent / HCl / 16.5 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2825 - 2829
反应条件
1: HI, AcOH 2: HCl View Scheme
参考文献
Archiv der Pharmazie, , vol. 305, # 2 p. 124 - 134
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 19, p. 1677 - 1693
反应条件
2: base hydrolysis 4: 1) potassium hexamethyldisilzide, 2) trisyl azide 5: 1) hydrogenation, 2) acid hydrolysis View Scheme
参考文献
Stone, Martin J.; Maplestone, Rachael A.; Man, Shirley K. Rah; Williams, Dudney H.
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2663 - 2666
反应条件
1.1: potassium carbonate; potassium iodide / acetone / 16 h / |Reflux 2.1: sodium hydroxide / water / 16 h / |Reflux 2.2: |Cooling with ice View Scheme
参考文献
Resch, Verena; Lechner, Horst; Schrittwieser, Joerg H.; Wallner, Silvia; Gruber, Karl; MacHeroux, Peter; Kroutil, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 41 p. 13173 - 13179
反应条件
(i) K2CO3, acetone, (ii) aq. KOH; Multistep reaction;
参考文献
Gerlach,H.
Helvetica Chimica Acta, 1977 , vol. 60, p. 3039 - 3044
参考文献
Stone, Martin J.; Maplestone, Rachael A.; Man, Shirley K. Rah; Williams, Dudney H.
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2663 - 2666
反应条件
2: base hydrolysis View Scheme
参考文献
Stone, Martin J.; Maplestone, Rachael A.; Man, Shirley K. Rah; Williams, Dudney H.
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2663 - 2666
反应条件
1: imidazole / dimethylformamide
2: toluene / 80 °C
3: 1) lithium diisopropylamide (LDA), 2) trisyl azide
4: H2 / Pd-C
5: 4) 105 deg C
View Scheme
参考文献
Stone, Martin J.; Maplestone, Rachael A.; Man, Shirley K. Rah; Williams, Dudney H.
Tetrahedron Letters, 1991 , vol. 32, # 23 p. 2663 - 2666
