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乙二醇
甲醛
63148-62-9
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二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
N-苄基-4-羟基哌啶
合成路线
(共 25 条)
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
50541-93-0
4-氨基-1-苄基哌啶
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72.33 h / 0 - 20 °C / Inert atmosphere 2: hydrazine hydrate / methanol / 24 h / 20 °C View Scheme
参考文献
Jakubowska, Anna; Kulig, Katarzyna; Natalia, Guzior; Malawska, Barbara
Acta Poloniae Pharmaceutica - Drug Research, 2012 , vol. 69, # 3 p. 449 - 455
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
28033-32-1
4-(2-甲氧基 苯氧基) 哌啶
反应条件
1: 43 percent / PPh3; diethyl azadicarboxylate / tetrahydrofuran / 96 h / 20 °C 2: 100 percent / H2 / Pd/C / ethanol / 20 °C View Scheme
参考文献
Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Tortorella, Vincenzo
Medicinal Chemistry Research, 1999 , vol. 9, # 5 p. 340 - 353
4727-72-4
N-苄基-4-羟基哌啶
+
95-57-8
邻氯苯酚
→
反应条件
900512-07-4
1-苄基-4-(2-氯苯氧基)哌啶
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane T=0°C; 72 h;
参考文献
Pfizer Inc
Patent: US2006/160786 A1, 2006 ;
Location in patent: Page/Page column 30 ;
US 20060160786 A1
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
67848-71-9
N-苄基-4-氯哌啶
反应条件
tetrachloromethane; triphenylphosphine on polystyrene in dichloromethane 12 h; Heating;
参考文献
Lizarzaburu, Mike E.; Shuttleworth, Stephen J.
Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4873 - 4876
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
127806-46-6
反应条件
1: 44 percent / KOH; 18-crown-6 / toluene / 24 h / Heating 2: 100 percent / H2 / Pd/C / ethanol / 20 °C View Scheme
参考文献
Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Tortorella, Vincenzo
Medicinal Chemistry Research, 1999 , vol. 9, # 5 p. 340 - 353
4727-72-4
N-苄基-4-羟基哌啶
+
107-13-1
丙烯腈
→
反应条件
175203-64-2
3-[(1-苄基-4-哌啶)氧基]丙腈
反应条件
N-benzyl-trimethylammonium hydroxide in acetonitrile T=80°C; 25 h;
参考文献
Maslowska-Lipowicz, Iwona; Figlus, Marek; Zuiderveld, Obbe P.; Walczynski, Krzysztof
Archiv der Pharmazie, 2008 , vol. 341, # 12 p. 762 - 773
4727-72-4
N-苄基-4-羟基哌啶
+
17337-13-2
异氰酸2-联苯酯
→
反应条件
171722-92-2
反应条件
1: T=70°C; 12 h; 2: With hydrogenchloride; ammonium formate; palladium 10 on activated carbon in etanol; water T=20 - 50°C; 12 h;
参考文献
Theravance, Inc.
Patent: US2005/203134 A1, 2005 ;
Location in patent: Page/Page column 17-18 ;
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
171722-92-2
反应条件
1: 70 °C / neat (no solvent) 2: 10 palladium on activated charcoal; NH4HCO3 / ethanol / 40 °C View Scheme
参考文献
Naito, Ryo; Takeuchi, Makoto; Morihira, Koichiro; Hayakawa, Masahiko; Ikeda, Ken; Shibanuma, Tadao; Isomura, Yasuo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1286 - 1294
4727-72-4
N-苄基-4-羟基哌啶
+
17337-13-2
异氰酸2-联苯酯
→
反应条件
171723-80-1
反应条件
1: T=70°C; 12 h; 2: With hydrogenchloride in ethanol; water T=50°C; 3: With Celite; ammonium formate; palladium 10 on activated carbon T=20 - 40°C; 12.33 h;
参考文献
Bolton, Jennifer; Chao, Robert S.; Rapta, Miroslav; Williams, Lisa; Wilson, Richard D.
Patent: US2007/249674 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
4727-72-4
N-苄基-4-羟基哌啶
→
反应条件
反应条件
triethylamine in toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US5753679 A1, 1998 ;
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