5-氯-3-((3,5-二甲基苯基)磺酰基)-1H-吲哚-2-羧酸合成路线 （共 5 条）
反应条件
lithium hydroxide in tetrahydrofuran
T=20°C; 24 h;
参考文献
Silvestri, Romano; Artico, Marino; De Martino, Gabriella; La Regina, Giuseppe; Loddo, Roberta; La Colla, Massimiliano; La Colla, Paolo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3892 - 3896
反应条件
lithium hydroxide monohydrate in tetrahydrofuran; ethanol; water
参考文献
LaColla, Paulo; Artico, Marino; Sommadossi, Jean-Pierre
Patent: US2002/193415 A1, 2002 ;
反应条件
1: BF3*Et2O / CH2Cl2 / 4 h / 20 - 45 °C
2: MCPBA / CHCl3 / 1 h / 20 °C
3: 94 percent / aq. LiOH / tetrahydrofuran / 24 h / 20 °C
View Scheme
参考文献
Silvestri, Romano; Artico, Marino; De Martino, Gabriella; La Regina, Giuseppe; Loddo, Roberta; La Colla, Massimiliano; La Colla, Paolo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3892 - 3896
反应条件
1: BF3*Et2O / CH2Cl2 / 4 h / 20 - 45 °C
2: MCPBA / CHCl3 / 1 h / 20 °C
3: 94 percent / aq. LiOH / tetrahydrofuran / 24 h / 20 °C
View Scheme
参考文献
Silvestri, Romano; Artico, Marino; De Martino, Gabriella; La Regina, Giuseppe; Loddo, Roberta; La Colla, Massimiliano; La Colla, Paolo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3892 - 3896
反应条件
1: MCPBA / CHCl3 / 1 h / 20 °C
2: 94 percent / aq. LiOH / tetrahydrofuran / 24 h / 20 °C
View Scheme
参考文献
Silvestri, Romano; Artico, Marino; De Martino, Gabriella; La Regina, Giuseppe; Loddo, Roberta; La Colla, Massimiliano; La Colla, Paolo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3892 - 3896
