5-氯-4-氟-1H-吲哚-2-羧酸乙酯合成路线 （共 2 条）
反应条件
iron in acetic acid
T=60°C;
参考文献
Piscitelli, Francesco; La Regina, Giuseppe; Silvestri, Romano
Organic Preparations and Procedures International, 2008 , vol. 40, # 2 p. 204 - 208
反应条件
1: 4-chloro-3-fluoroaniline With hydrogenchloride; sodium nitrite in water
T=0°C; 0.5 h;
2: With sodium acetate in water
0.5 h;
3: 2-methyl-3-oxobutanoic acid ethyl ester With potassium acetate
more than 3 stages;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 187-188 ;
