3,6-二羟基邻苯二甲腈合成路线 （共 41 条）
反应条件
1: pyridine / dichloromethane / 24 h / -78 - 20 °C
2: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C
View Scheme
参考文献
Sakamoto, Keiichi; Yoshino, Satoru; Takemoto, Makoto; Furuya, Naoki
Journal of Porphyrins and Phthalocyanines, 2013 , vol. 17, # 8-9 p. 605 - 627
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 30 percent / Zn(Hg); HCl; glacial AcOH / Heating
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 92 percent / Cs2CO3; KI / dimethylformamide / 8 h / 20 °C
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 92 percent / Cs2CO3; KI / dimethylformamide / 8 h / 20 °C
4: 100 percent / sodium borohydride / methanol; CHCl3 / 1 h / 0 °C
5: 81 percent / TFA; triethylsilane / CH2Cl2 / 0.25 h / 0 °C
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 92 percent / Cs2CO3; KI / dimethylformamide / 8 h / 20 °C
4: 100 percent / sodium borohydride / methanol; CHCl3 / 1 h / 0 °C
5: 81 percent / TFA; triethylsilane / CH2Cl2 / 0.25 h / 0 °C
6: 73 percent / MgBr2*OEt2 / toluene; diethyl ether / Heating
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 92 percent / Cs2CO3; KI / dimethylformamide / 8 h / 20 °C
4: 100 percent / sodium borohydride / methanol; CHCl3 / 1 h / 0 °C
5: 81 percent / TFA; triethylsilane / CH2Cl2 / 0.25 h / 0 °C
6: 73 percent / MgBr2*OEt2 / toluene; diethyl ether / Heating
7: 91 percent / K2CO3 / acetone / 8 h / Heating
8: 100 percent / hydrogen / Pd/C / methanol; ethyl acetate / atmospheric pressure
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
1: KOH / H2O / 3 h / Heating
2: 25 percent / dicyclohexylurea / tetrahydrofuran / 10 h / Heating
3: 92 percent / Cs2CO3; KI / dimethylformamide / 8 h / 20 °C
4: 100 percent / sodium borohydride / methanol; CHCl3 / 1 h / 0 °C
5: 81 percent / TFA; triethylsilane / CH2Cl2 / 0.25 h / 0 °C
6: 73 percent / MgBr2*OEt2 / toluene; diethyl ether / Heating
7: 91 percent / K2CO3 / acetone / 8 h / Heating
8: 100 percent / hydrogen / Pd/C / methanol; ethyl acetate / atmospheric pressure
9: 52 percent / bromine; glacial AcOH; NaOAc*3H2O / 0.5 h / 20 °C
View Scheme
参考文献
Le Vezouet, Ronan; White, Andrew J.P.; Burrows, Jeremy N.; Barrett, Anthony G.M.
Tetrahedron, 2006 , vol. 62, # 52 p. 12252 - 12263
反应条件
N-bromosuccinmide in tert-butyl alcohol
T=45°C; 4.83 h;
参考文献
Al-Raqa, Shaya Y.; Messali, Mouslim; Al-Refae, Saleem; Ghanem, Badr S.; Moussa, Ziad; Ahmed, Saleh; El-Khouly, Mohamed E.; Fukuzumi, Shunichi
Dyes and Pigments, 2011 , vol. 91, # 2 p. 231 - 236
反应条件
methanol; potassium carbonate
参考文献
Thiele; Guenther
Justus Liebigs Annalen der Chemie, 1906 , vol. 349, p. 64
反应条件
sodium hydroxide
1.) water, reflux, 7 h; 2.) toluene, reflux; Multistep reaction;
参考文献
Inukai; Furukawa; Inoue; Terashima
Molecular crystals and liquid crystals, 1983 , vol. 94, # 1-2 p. 109 - 118
