1-氮杂双环[3.2.2]壬烷-3-酮合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
6 h; Heating;
参考文献
Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
6 h; Heating;
参考文献
Walker, Daniel P.; Acker, Brad A.; Jacobsen, E. Jon; Wishka, Donn G.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 247 - 257
反应条件
1: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 2585.81 Torr
2: chloro-trimethyl-silane; trimethylphenylammonium monobromide; lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 - 0 °C
3: dichloromethane / 0.5 h / 0 °C
4: N-ethyl-N,N-diisopropylamine / acetonitrile
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
反应条件
1: Sodium hydride / tetrahydrofuran / 2.67 h / 0 - 20 °C / Heating / reflux
2: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 2585.81 Torr
3: chloro-trimethyl-silane; trimethylphenylammonium monobromide; lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 - 0 °C
4: dichloromethane / 0.5 h / 0 °C
5: N-ethyl-N,N-diisopropylamine / acetonitrile
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
反应条件
1: dichloromethane / 0.5 h / 0 °C
2: N-ethyl-N,N-diisopropylamine / acetonitrile
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
反应条件
1: chloro-trimethyl-silane; trimethylphenylammonium monobromide; lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 - 0 °C
2: dichloromethane / 0.5 h / 0 °C
3: N-ethyl-N,N-diisopropylamine / acetonitrile
View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
