1,4-苯并二氧六环-2-甲酸乙酯合成路线 （共 44 条）
参考文献
Koo et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5373
反应条件
ammonium hydroxide; ethanol
参考文献
Koo et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5373
反应条件
1: 1.) AlCl3, 2.) 28percent NH4OH / 1.) CS2, 0 deg C, 2.) EtOH 2: 57 percent / HCl / Heating 3: 1.) MCPBA, 2.) 10 N KOH / 1.) CH2Cl2, reflux, 18 h 4: 1.) KOH, 2.) HCl 5: 80 percent / EDCl, DMAP / CH2Cl2 6: BBr3 / CH2Cl2 / Ambient temperature 7: 1.) APTS, 2.) Et3N / 1.) reflux 8: 1.) H2, 2.) LiAlH4 / 1.) Pd/C / 1.) MeOH, 2.) Et2O, reflux View Scheme
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 20 °C 2: 96 percent / NBS; PPh3 / dimethylformamide / 6 h / 40 °C View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
1: 75 percent / toluene; H2O / 40 h / 35 °C
2: LiAlH4 / tetrahydrofuran / 24 h / 50 °C
3: 50 percent / K2CO3 / dimethylformamide / 48 h / 80 °C
View Scheme
参考文献
Sanchez, Isabel; Dolors Pujol, Maria; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Dureng, Georges; Winslow, Eileen
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 7-8 p. 663 - 676
反应条件
aluminium trichloride in carbon disulfide
T=0°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Khouili; Guillaumet; Coudert; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 175 - 184
反应条件
1: 1.) AlCl3, 2.) 28percent NH4OH / 1.) CS2, r.t., overnight, 2.) EtOH, r.t., 72 h
2: 75 percent / HCl / 24 h / Heating
View Scheme
参考文献
Khouili; Lazar; Guillaumet; Coudert
Tetrahedron Asymmetry, 1994 , vol. 5, # 4 p. 535 - 536
反应条件
aluminium trichloride; N,N-dimethyl-formamide
12 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Suarez, Alejandra G.
Tetrahedron Letters, 1999 , vol. 40, # 18 p. 3523 - 3526
反应条件
aluminium trichloride in carbon disulfide
T=0°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Khouili; Guillaumet; Coudert; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 175 - 184
反应条件
aluminium trichloride; N,N-dimethyl-formamide
12 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Suarez, Alejandra G.
Tetrahedron Letters, 1999 , vol. 40, # 18 p. 3523 - 3526
