1,4-苯并二氧六环-2-甲酸乙酯合成路线 （共 44 条）
反应条件
sodium hydride in dimethyl sulfoxide
0.25 h;
参考文献
Rosnati, Vittorio; Salimbeni, Aldo
Tetrahedron, 1986 , vol. 42, # 16 p. 4541 - 4548
反应条件
1: 24 percent / esterase from Serracia marcescens; aq. NaHCO3; aq. NaOH / toluene / 19.5 h / 25 °C / pH 8.5 - 9.0
2: SOCl2 / CDCl3 / 1.5 h / 84 °C
3: 1.86 kg / conc. HCl / H2O; methanol / 4.5 h / 30 - 35 °C
View Scheme
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
1: 1.) NaOH; 2.) SOCl2
2: H2O; CHCl3 / 2 h / 20 °C
3: LiAlH4 / tetrahydrofuran / 12 h / Heating
4: 6N HCl / H2O / 12 h / Ambient temperature
View Scheme
参考文献
Mauleon; Antunez; Rosell
Farmaco, 1989 , vol. 44, # 11 p. 1109 - 1117
反应条件
1: 99 percent / N-bromosuccinimide, CaCO3, benzoyl peroxide / 18 h / Heating
2: 94 percent / sodium iodide / acetone / Ambient temperature
View Scheme
参考文献
Cooney, Mark J.; Halton, Brian
Australian Journal of Chemistry, 1996 , vol. 49, # 4 p. 533 - 538
