1: With Cs2C03 in acetone
2 h; Heating / reflux;
2: With N,N-dimethyl-formamide in acetone
T=70°C; 12 h;
3: With acetic acid; hydrazine in water
T=20°C; 18 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/31178 A1, 2004 ;
Location in patent: Page column 28 ;