2-氯-1-环丙基-1,3-丁二酮合成路线 （共 2 条）
反应条件
chloro-trimethyl-silane; tetrabutylammomium bromide; dimethyl sulfoxide in acetonitrile
T=0 - 20°C; 1.5 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/24147 A1, 2004 ;
Location in patent: Page/Page column 21 ;
WO 2004/024147 A1
反应条件
1: With chloro-trimethyl-silane in dichloromethane
T=0 - 5°C; 0.5 h; Inert atmosphereLarge scale reaction;
2: With N-chloro-succinimide in dichloromethane
T=0 - 5°C; 2.08333 h; Inert atmosphereLarge scale reaction;
参考文献
Bradley, Paul A.; De Koning, Pieter D.; Johnson, Patrick S.; Lecouturier, Yann C.; McManus, David J.; Robin, Aurelie; Underwood, Toby J.
Organic Process Research and Development, 2009 , vol. 13, # 5 p. 848 - 853
