1-烯丙基-1H-吡咯-2-羧酸合成路线 （共 4 条）
反应条件
lithium hydroxide; water in tetrahydrofuran; methanol
T=20 - 60°C; 13 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1386913 A1, 2004 ;
Location in patent: Page 89 ;
反应条件
1: With sodium hydroxide in ethanol; water
1.5 h; RefluxInert atmosphere;
2: With hydrogenchloride in water
pH=2; Inert atmosphere;
参考文献
Nicolai, Stefano; Piemontesi, Cyril; Waser, Jerome
Angewandte Chemie - International Edition, 2011 , vol. 50, # 20 p. 4680 - 4683
反应条件
potassium hydroxide in dimethyl sulfoxide
参考文献
Mai; Artico, Marino; Esposito; Ragno; Sbardella; Massa
Farmaco, 2003 , vol. 58, # 3 p. 231 - 241
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / ethanol; water / 1.5 h / Reflux; Inert atmosphere
2.2: pH 2 / Inert atmosphere
View Scheme
参考文献
Nicolai, Stefano; Piemontesi, Cyril; Waser, Jerome
Angewandte Chemie - International Edition, 2011 , vol. 50, # 20 p. 4680 - 4683
