1-(1,3-二氧戊环-2-亚基)-1H-茚-3-甲腈合成路线 （共 6 条）
反应条件
1: With sulfuric acid; hydrogen; palladium on activated charcoal in methanol 2: With sodium t-butanolate in isopropyl alcohol
参考文献
Singer, Robert A.; McKinley, Jason D.; Barbe, Guillaume; Farlow, Robin A.
Organic Letters, 2004 , vol. 6, # 14 p. 2357 - 2360
反应条件
1: With sulfuric acid T=0 - 5°C; 2: With hydrogen; palladium on activated carbon T=0 - 55°C; P=2585.81 Torr;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/63164 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
sulfuric acid; hydrogen; palladium on activated charcoal in methanol T=50°C; P=2585.81 Torr;
参考文献
Busch, Frank R.; Concannon, Paul E.; Handfield, Robert E.; McKinley, Jason D.; McMahon, Megan E.; Singer, Robert A.; Watson, Timothy J.; Withbroe, Gregory J.; Stivanello, Mariano; Leoni, Lucia; Bezze, Chiara
Synthetic Communications, 2008 , vol. 38, # 3 p. 441 - 447
反应条件
1: ethyl 3-ethoxypropenoate; 2-(2'-bromophenyl)-acetonitrile With sodium t-butanolate; tri-cyclo-hexyl-phosphine; palladium diacetate in tetrahydrofuran
T=60°C; 2.5 h;
2: ethylene glycol With sulfuric acid in tetrahydrofuran
T=20°C; 15 h;
参考文献
Singer, Robert A.; McKinley, Jason D.; Barbe, Guillaume; Farlow, Robin A.
Organic Letters, 2004 , vol. 6, # 14 p. 2357 - 2360
反应条件
1: in tetrahydrofuran
T=5°C;
2: With sulfuric acid in water
T=10 - 40°C; 12.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/48318 A1, 2004 ;
Location in patent: Page 7-8 ;
反应条件
sulfuric acid; sodium t-butanolate in tetrahydrofuran; ethylene glycol
参考文献
Singer, Robert A.
Patent: US2003/60624 A1, 2003 ;
