4-(2-硝基-4-(三氟甲基)苯基)哌嗪-1-羧酸叔丁酯合成路线 (共 3 条)
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KOWALSKI, Jennifer A.; MARSHALL, Daniel Richard; PROKOPOWICZ, Anthony S. III; SCHLYER, Sabine; SIBLEY, Robert; SORCEK, Ronald John; WU, Di; WU, Frank; YOUNG, Erick Richard Roush
Patent: WO2010/126811 A1, 2010 ;
Location in patent: Page/Page column 137-138 ;
WO 2010/126811 A1
反应条件
triethylamine
T=20°C; 3 h;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 204 ;
WO 2005/075425 A2
反应条件
hydrogen; nickel in methanol
T=20°C;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 204 ;
WO 2005/075425 A2