(3S)-3-甲基-1-(2-吡啶基)哌嗪合成路线 （共 4 条）
反应条件
1: With trifluoroacetic acid in dichloromethane
T=20°C;
2: With water; sodium carbonate in dichloromethane
pH=8;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 197-198 ;
参考文献
Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey
Patent: US2002/169166 A1, 2002 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 120 °C
2.1: trifluoroacetic acid / dichloromethane / 20 °C
2.2: pH 8
View Scheme
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 120 °C
2.1: trifluoroacetic acid / dichloromethane / 20 °C
2.2: pH 8
View Scheme
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
