(3R)-3-甲基-1-(2-吡啶基)哌嗪合成路线 （共 4 条）
反应条件
hydrogenchloride; sodium chloride; sodium hydrogencarbonate; sodium carbonate in water
参考文献
Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey
Patent: US2002/169167 A1, 2002 ;
反应条件
in xylene
T=140°C; 13 h;
参考文献
Applied Research Systems ARS Holding N.V.
Patent: WO2006/10751 A1, 2006 ;
Location in patent: Page/Page column 73 ;
反应条件
1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate / 1,4-dioxane / 0.17 h / 120 °C / |Microwave irradiation
2: hydrogenchloride / methanol; water; 1,4-dioxane
View Scheme
参考文献
Lovell, Kimberly M.; Felts, Andrew S.; Rodriguez, Alice L.; Venable, Daryl F.; Cho, Hyekyung P.; Morrison, Ryan D.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3713 - 3718
反应条件
1: 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate / 1,4-dioxane / 0.17 h / 120 °C / |Microwave irradiation
2: hydrogenchloride / methanol; water; 1,4-dioxane
View Scheme
参考文献
Lovell, Kimberly M.; Felts, Andrew S.; Rodriguez, Alice L.; Venable, Daryl F.; Cho, Hyekyung P.; Morrison, Ryan D.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3713 - 3718
