1,4-环己二酮单乙二醇缩酮合成路线

参考文献

Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6

106-39-84-溴氯苯+

4746-97-81,4-环己二酮单乙二醇缩酮

126991-59-18-(4-氯苯基)-1,4-二氧杂螺[4.5]癸烷-8-醇

参考文献

WO2012/153162 A1, ;

Page/Page column 36 ;

4746-97-81,4-环己二酮单乙二醇缩酮+

637-87-6对氯碘苯

126991-59-18-(4-氯苯基)-1,4-二氧杂螺[4.5]癸烷-8-醇

参考文献

Tetrahedron Letters, , vol. 39, # 42 p. 7629 - 7632

4746-97-81,4-环己二酮单乙二醇缩酮

126991-59-18-(4-氯苯基)-1,4-二氧杂螺[4.5]癸烷-8-醇

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4910 - 4914

4746-97-81,4-环己二酮单乙二醇缩酮

13482-24-14-羟基环己酮-d4

参考文献

Green,M.M.; Djerassi,C.
Journal of the American Chemical Society, 1967 , vol. 89, p. 5190 - 5198

120-72-9吲哚+

4746-97-81,4-环己二酮单乙二醇缩酮

143165-32-6

参考文献

Wustrow, David J.; Smith III, William J.; Corbin, Ann E.; Davis, M. Duff; Georgic, Lynn M.; Pugsley, Thomas A.; Whetzel, Steven Z.; Heffner, Thomas G.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 250 - 259

123-75-1四氢吡咯+

120-72-9吲哚+

4746-97-81,4-环己二酮单乙二醇缩酮

143165-32-6

参考文献

Bristol-Myers Squibb Company
Patent: US4954502 A1, 1990 ;

4746-97-81,4-环己二酮单乙二醇缩酮

1341224-83-6PF-4136309

参考文献

Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; Kong, Lingquan; Glenn, Joseph; Anand, Rajan; Meloni, David; Robinson; Shao, Lixin; Storace, Lou; Li, Mei; Hughes, Robert O.; Devraj, Rajesh; Morton, Philip A.; Rogier, D. Joseph; Covington, Maryanne; Scherle, Peggy; Diamond, Sharon; Emm, Tom; Yeleswaram, Swamy; Contel, Nancy; Vaddi, Kris; Newton, Robert; Hollis, Greg; Metcalf, Brian
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 12 p. 913 - 918

4746-97-81,4-环己二酮单乙二醇缩酮

13482-22-94-羟基环己酮

参考文献

SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho
Patent: WO2011/139107 A2, 2011 ;
Location in patent: Page/Page column 89 ;
WO 2011/139107 A2

4746-97-81,4-环己二酮单乙二醇缩酮

126991-60-48-(4-氯苯基)-1,4-二噁螺[4.5]-7-癸烯

参考文献

Journal of the American Chemical Society, , vol. 134, # 41 p. 17023 - 17026,4