1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
1.1: 90 percent / NaH / dimethylsulfoxide 2.1: Cu-Zn / diethyl ether / 29 h / Heating 2.2: 48 percent / 1M HCl / 1 h / 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BROCHU, Christian; GRAND-MAÎTRE, Chantal; FADER, Lee; KUHN, Cyrille; BERTRAND-LAPERLE, Mégan; PESANT, Marc
Patent: WO2013/26163 A1, 2013 ;
反应条件
potassium hydroxide in methanol 18 h; Heating;
参考文献
Wustrow, David J.; Smith III, William J.; Corbin, Ann E.; Davis, M. Duff; Georgic, Lynn M.; Pugsley, Thomas A.; Whetzel, Steven Z.; Heffner, Thomas G.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 250 - 259
反应条件
1.1: toluene / 2 h / Reflux 1.2: 15 - 20 °C 2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 24 h / 80 °C 3.1: hydrogenchloride; water / 2 h / 60 °C View Scheme
反应条件
sodium tetrahydroborate in methanol 2.5 h;
参考文献
CRYPTOPHARMA PTY LTD
Patent: WO2008/124878 A1, 2008 ;
Location in patent: Page/Page column 82-83 ;
反应条件
hydrogenchloride in methanol; 1-t-Butyl carbamate-3-trifluoromethane sulfonoxy-1-cyclopentane-1-carboxylic carboxylic acid methyl ester
参考文献
Emory University
Patent: US5817776 A1, 1998 ;
反应条件
sodium hydroxide; sodium borohydride in methanol
参考文献
Hirst, Gavin C.; Calderwood, David; Munschauer, Rainer; Arnold, Lee D.; Johnston, David N.; Rafferty, Paul
Patent: US2003/153752 A1, 2003 ;
反应条件
triethylsilane; NaPF6; dirhenium heptaoxide in dichloromethane T=50°C; 60 h; chemoselective reaction;
参考文献
Das, Braja Gopal; Ghorai, Prasanta
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 26 p. 4379 - 4382
反应条件
N-methylaniline; toluene-4-sulfonic acid in toluene 30 h; Heating;
参考文献
Haga, Kazuo; Oohashi, Masayuki; Kaneko, Ryohei
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 6 p. 1586 - 1590
反应条件
1: 65 percent / NH3 / methanol / 8 h / 100 °C 2: 95 percent / Ag2CO3 / CHCl3 / 2.5 h / Heating 3: 90 percent / HCl / acetone; H2O / 3 h / Heating View Scheme
参考文献
Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4636 - 4645
反应条件
N,N'-dimethyl-N,N'-propyleneurea; sodium hydride in tetrahydrofuran; paraffin 12 h;
参考文献
Tetrahedron, , vol. 51, # 37 p. 10259 - 10280
