反应条件
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 - 25 °C / |Inert atmosphere
2.1: pyridine / toluene / 16 h / |Reflux
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 - -60 °C
3.2: 3 h / -78 °C
4.1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / |Inert atmosphere
5.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C
6.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / -25 °C
7.1: methanol; lithium hydroxide hydrate / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1893 - 1901
