1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
in methanol; water
T=20°C; 65 h;
参考文献
Gruenenthal GmbH
Patent: US2004/214822 A1, 2004 ;
Location in patent: Page 10 ;
US 20040214822 A1
反应条件
1: lithium aluminium tetrahydride / diethyl ether
2: triethylamine / dichloromethane
3: hydrogenchloride / water; 1,4-dioxane
View Scheme
参考文献
Heugebaert, Thomas S.A.; Van Overtveldt, Melissa; De Blieck, Ann; Wuyts, Benjamin; Augustijns, Patrick; Ponce-Gamez, Eugenia; Rivera, Alicia; De Groote, Dominic; Lefebvre, Romain A.; Wouters, Patrick; Meert, Theo; Devulder, Jacques; Stevens, Christian V.
RSC Advances, 2014 , vol. 4, # 5 p. 2226 - 2234
反应条件
1: 91 percent / diethyl ether / 2 h / -78 °C
2: 1.) BF3*Et2O / 1.) CH2Cl2, -78 deg C, 20 min, 2.) CH2Cl2, from -78 deg C to RT, overnight
View Scheme
参考文献
Liu; Wu; Burnell
Canadian Journal of Chemistry, 1997 , vol. 75, # 6 p. 656 - 664
反应条件
in tetrahydrofuran
T=20°C;
参考文献
Paquette, Leo A.; Shetuni, Brandon B.; Gallucci, Judith C.
Organic Letters, 2003 , vol. 5, # 15 p. 2639 - 2642
Title/Abstract Full Text View citing articles Show Details
Ohkata, Katsuo; Tamura, Yukiko; Shetuni, Brandon B.; Takagi, Ryukichi; Miyanaga, Wataru; Kojima, Satoshi; Paquette, Leo A.
Journal of the American Chemical Society, 2004 , vol. 126, # 51 p. 16783 - 16792
反应条件
1.1: tetrahydrofuran / 20 °C / Reflux
1.2: 0 °C
2.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C
2.2: 0 °C
View Scheme
参考文献
Bayer CropScience AG
Patent: US2011/263424 A1, 2011 ;
反应条件
1.1: NaBH4 / methanol / 3 h / 0 °C
2.1: KH / tetrahydrofuran / 0 - 20 °C
2.2: 83 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
SYNGENTA LIMITED; FOLEY, Daniel Jason; JEANMART, Stephane Andre Marie; LONGSTAFF, Adrian; PARSONS, Robert William; RUSSELL, Claire Janet; TAYLOR, John Benjamin; WAILES, Jeffrey, Steven
Patent: WO2011/7146 A1, 2011 ;
反应条件
1: Wittig reaction;
2: With borane-THF
3: With pyridinium chlorochromate
Further stages.;
参考文献
Vila, Xavier; Quirante, Josefina; Paloma, Laura; Bonjoch, Josep
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4661 - 4664
反应条件
1: in tetrahydrofuran
T=10 - 20°C; 2 h;
2: With ammonium chloride in tetrahydrofuran
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/114223 A1
反应条件
in tetrahydrofuran
T=10 - 20°C; 2 h;
参考文献
Xue, Chu-Biao; Metcalf, Brian W.; Han, Amy Qi; Robinson, Darius J.; Zheng, Changsheng; Wang, Anlai; Zhang, Yingxin
Patent: US2005/192302 A1, 2005 ;
Location in patent: Page/Page column 22 ;
US 20050192302 A1
反应条件
tert.-butyl lithium
1.) THF, -60 deg C, 3 h, 2.) THF, RT, overnight; Yield given. Multistep reaction;
参考文献
Li, Gang; Xie, Jian-Hua; Hou, Jing; Zhu, Shou-Fei; Zhou, Qi-Lin
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 8 p. 1597 - 1604
