1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
1: benzene; toluene-4-sulfonic acid 2: chromium (VI)-oxide; pyridine View Scheme
参考文献
Plieninger; Grasshoff
Chemische Berichte, 1957 , vol. 90, p. 1973,1944
参考文献
Gardner et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 1206,1209
反应条件
1: 98 percent / NaBH4 / methanol / 1.) 0 deg C, 0.5 h, 2.) room temperature, 1 h 2: 83 percent / KOH / dimethylsulfoxide / Ambient temperature 3: oxalic acid / CH2Cl2; H2O / Ambient temperature 4: NaBH4 / methanol / 0 - 20 °C View Scheme
参考文献
Shvily, Ronit; Mueller, Thomas; Apeloig, Yitzhak; Mandelbaum, Asher
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 6 p. 1221 - 1234
反应条件
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 50 °C / Inert atmosphere 1.2: 16.75 h / 50 °C 2.1: toluene-4-sulfonic acid; water / acetone / 3.5 h / Reflux 3.1: potassium tert-butylate / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere 4.1: aluminum isopropoxide / toluene / 7 h / Reflux 4.2: 20 °C View Scheme
参考文献
NEO ONCOLOGY INC.; CHEN, Thomas; LEVIN, Daniel; PUPPALI, Satish; DICKMAN, Daniel, A.
Patent: WO2012/83178 A1, 2012 ;
反应条件
1: NaBH(AcO)3, CH3COOH / 1,2-dichloro-ethane / 24 h / Ambient temperature 2: 2.634 g / conc. aq. HCl / 48 h / Ambient temperature View Scheme
参考文献
Castan; Bigg
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 1125 - 1128
反应条件
disodium hydrogenphosphate; CF3CO3H in dichloromethane
参考文献
Heathcock, Clayton H.; Geldern, Thomas W. von
Heterocycles, 1987 , vol. 25, p. 75 - 78
反应条件
in dichloromethane T=40°C; Baeyer-Villiger oxidation; 5 h;
参考文献
Zou, Jie; Yang, Ye; Liu, Yaowen; Chen, Fang; Li, Xiaohong
Polymer, 2011 , vol. 52, # 15 p. 3357 - 3367
反应条件
1: CeCl3*7H2O; NaBH4 / methanol / 0.5 h / 20 °C 2: imidazole / dimethylformamide / 20 °C 3: 81 percent / NaI; CeCl3*7H2O / acetonitrile / 1 h / Heating View Scheme
参考文献
Majewski, Marek; Mackinnon, John
Canadian Journal of Chemistry, 1994 , vol. 72, # 7 p. 1699 - 1704
反应条件
1: 83 percent / tBuLi / tetrahydrofuran / -60 °C 2: 98 percent / PPTS / acetone; H2O / Heating View Scheme
参考文献
Williams, David R.; Clark, Michael P.
Tetrahedron Letters, 1998 , vol. 39, # 42 p. 7629 - 7632
反应条件
1.1: 60 percent / NaH / dimethylsulfoxide / 16 h / 50 °C 2.1: H2 / Pd/C / ethyl acetate / 24 h / 20 °C / 7500.6 Torr 2.2: 6.56 g / AcOH; H2O / tetrahydrofuran / 15 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 19 p. 4103 - 4106
