1,4-环己二酮单乙二醇缩酮合成路线 （共 270 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere 1.2: 1.33 h / -78 °C / Inert atmosphere 2.1: hydrogenchloride; water / tetrahydrofuran View Scheme
参考文献
Zhang, Xuqing; Hou, Cuifen; Hufnagel, Heather; Singer, Monica; Opas, Evan; McKenney, Sandra; Johnson, Dana; Sui, Zhihua
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 12 p. 1039 - 1044
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=20°C; 2: With sodium hydroxide; water in 1,2-dichloro-ethane 0.333333 h; Product distribution / selectivity;
参考文献
EISAI R andamp; D MANAGEMENT CO. LTD; GRACZYK, Piotr; BHATIA, Gurpreet, Singh
Patent: WO2010/15803 A1, 2010 ;
Location in patent: Page/Page column 34 ;
WO 2010/015803 A1
反应条件
1: 65 percent / NH3 / methanol / 8 h / 100 °C 2: 95 percent / Ag2CO3 / CHCl3 / 2.5 h / Heating 3: 90 percent / HCl / acetone; H2O / 3 h / Heating 4: 87 percent / NaH / tetrahydrofuran / 3.5 h / Heating View Scheme
参考文献
Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4636 - 4645
反应条件
1: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 20 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
GRUeNENTHAL GMBH
Patent: WO2005/105759 A1, 2005 ;
Location in patent: Page/Page column 90 ;
反应条件
1: montmorillonite K10 clay / microwave irradiation 2: montmorillonite K10 clay; sodium borohydride; water / 0.03 h / microwave irradiation View Scheme
参考文献
Hassner, Alfred; Belostotskii, Anatoly M.
Tetrahedron Letters, 1995 , vol. 36, # 10 p. 1709 - 1712
反应条件
1: NaBH4 / methanol / 3 h / 0 °C 2: 100 percent / imidazole / dimethylformamide / 4 h / 20 °C 3: 97 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Majewski, Marek; Mackinnon, John
Canadian Journal of Chemistry, 1994 , vol. 72, # 7 p. 1699 - 1704
反应条件
NaH in tetrahydrofuran; diethyl ether
参考文献
US2003/23098 A1, ;
US 20030023098 A1
反应条件
1: benzo[b]thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran; hexane T=-78 - 20°C; 0.166667 h; 3: With water in tetrahydrofuran; hexane
参考文献
US2009/54454 A1, ;
Page/Page column 20-21 ;
US 20090054454 A1
反应条件
1: benzene / Heating 2: 63 percent / NaNH2-t-BuONa / 2-methyl-propan-2-ol; tetrahydrofuran / 0 deg C -> room temp., 24 h View Scheme
参考文献
Caubere, Catherine; Caubere, Paul; Ianelli, Sandra; Nardelli, Mario; Jamart-Gregoire, Brigitte
Tetrahedron, 1994 , vol. 50, # 41 p. 11903 - 11920
反应条件
1: Mg / tetrahydrofuran / Heating 2: PTS / xylene; ethane-1,2-diol / Heating View Scheme
参考文献
JNC Corporation; JNC Petrochemical Corporation; MASUKAWA, Tokifumi
Patent: EP2690103 A1, 2014 ;
