甲基N-[2-乙基-6-(三氟甲基)-1,2,3,4-四氢喹啉-4-基]氨基甲酸酯合成路线 （共 14 条）
反应条件
1.1: sodium carbonate / dichloromethane / 2 h / |Inert atmosphere
2.1: caesium carbonate / toluene / 1 h / 20 °C / |Inert atmosphere
2.2: 16 h / 20 - 79 °C / |Inert atmosphere
3.1: sulfuric acid; water / 17 h / 35 °C / |Inert atmosphere; |Large scale
4.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale
5.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale
5.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
1.1: sulfuric acid; water / 17 h / 35 °C / |Inert atmosphere; |Large scale
2.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale
3.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale
3.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
1.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale
2.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale
2.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
pyridine in dichloromethane
T=-10 - 0°C; 20 h; Inert atmosphereLarge scale;
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
