(R)-3-氨基戊腈甲烷磺酸盐合成路线 （共 8 条）
反应条件
1.1: sodium carbonate / dichloromethane / 2 h / |Inert atmosphere 2.1: caesium carbonate / toluene / 1 h / 20 °C / |Inert atmosphere 2.2: 16 h / 20 - 79 °C / |Inert atmosphere 3.1: sulfuric acid; water / 17 h / 35 °C / |Inert atmosphere; |Large scale 4.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale 5.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale 5.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale 6.1: pyridine / dichloromethane / 20 h / -10 - 0 °C / |Inert atmosphere; |Large scale 7.1: potassium tert-butylate / 0.08 h / 20 °C / |Inert atmosphere; |Large scale 7.2: 4.5 h / 20 - 25 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
in ethyl acetate
T=20 - 70°C;
参考文献
Allen, David Robert; Achenbach-McCarthy, Crystal A.
Patent: US2004/2615 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
in ethyl acetate
T=20°C; 16 h;
参考文献
PCBU SERVICES, INC.
Patent: WO2004/58701 A2, 2004 ;
Location in patent: Page 22 ;
反应条件
in tetrahydrofuran
T=40 - 65°C; 6.5 h;
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
1: palladium diacetate; caesium carbonate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; 3,4,5-trimethoxyphenylboronic acid / dichloromethane; toluene / 80 °C
2: sulfuric acid / toluene / 35 °C
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
1.1: sodium carbonate / dichloromethane / 2 h / |Inert atmosphere
2.1: caesium carbonate / toluene / 1 h / 20 °C / |Inert atmosphere
2.2: 16 h / 20 - 79 °C / |Inert atmosphere
3.1: sulfuric acid; water / 17 h / 35 °C / |Inert atmosphere; |Large scale
4.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale
5.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale
5.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
1.1: sodium carbonate / dichloromethane / 2 h / |Inert atmosphere
2.1: caesium carbonate / toluene / 1 h / 20 °C / |Inert atmosphere
2.2: 16 h / 20 - 79 °C / |Inert atmosphere
3.1: sulfuric acid; water / 17 h / 35 °C / |Inert atmosphere; |Large scale
4.1: lithium tert-butylate / tetrahydrofuran; di-isopropyl ether / 0.17 h / 2 - 5 °C / |Inert atmosphere; |Large scale
5.1: sodium tetrahydroborate / toluene; ethanol; water / 0.33 h / 20 °C / |Inert atmosphere; |Large scale
5.2: 0.75 h / -10 - 0 °C / |Inert atmosphere; |Large scale
6.1: pyridine / dichloromethane / 20 h / -10 - 0 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
反应条件
sodium hydroxide in water
参考文献
Damon, David B.; Dugger, Robert W.; Hubbs, Stephen E.; Scott, Jill M.; Scott, Robert W.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 472 - 480
