6-溴-3-碘咪唑并[1,2-A]吡啶合成路线 （共 3 条）
反应条件
1: 6-bromo-3-iodoimidazo[1,2-a]pyridine With iso-propylmagnesium bromide in tetrahydrofuran T=0 - 20°C; 2: chloroformic acid ethyl ester in tetrahydrofuran T=-60 - 0°C; Cooling with acetone-dry ice;
参考文献
EP1382603 A1, ;
Page 144 ;
反应条件
N-iodo-succinimide in acetonitrile
T=20°C; 1 h;
参考文献
El Akkaoui, Ahmed; Bassoude, Ibtissam; Koubachi, Jamal; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald
Tetrahedron, 2011 , vol. 67, # 37 p. 7128 - 7138
反应条件
1: sodium hydrogencarbonate / isopropyl alcohol / 24 h / 100 °C / Inert atmosphere
2: N-iodo-succinimide / acetonitrile / 12 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Kim, Okseon; Jeong, Yujeong; Lee, Hyunseung; Hong, Sun-Sun; Hong, Sungwoo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2455 - 2466
