6-溴-咪唑并[1,2-a]吡啶-3-甲腈合成路线 （共 3 条）
反应条件
sodium hydrogencarbonate in isopropyl alcohol
T=100°C; 12 h; Inert atmosphere;
参考文献
Kim, Okseon; Jeong, Yujeong; Lee, Hyunseung; Hong, Sun-Sun; Hong, Sungwoo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2455 - 2466
反应条件
sodium hydrogencarbonate in isopropyl alcohol
T=100°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/55418 A1, 2009 ;
Location in patent: Page/Page column 65-66 ;
WO 2009/055418 A1
反应条件
1: methanol / 6 h / 70 °C / Inert atmosphere
2: sodium hydrogencarbonate / isopropyl alcohol / 12 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Kim, Okseon; Jeong, Yujeong; Lee, Hyunseung; Hong, Sun-Sun; Hong, Sungwoo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2455 - 2466
