1-(4-氟苯基)-环丙胺合成路线 （共 3 条）
反应条件
1: With titanium(IV) isopropylate in diethyl ether
T=-70 - 20°C; 2 h;
2: With boron trifluoride diethyl etherate in diethyl ether
T=20°C;
参考文献
SHIONOGI andamp;; CO., LTD.; MIKAMIYAMA, Hidenori; MATSUMURA, Akira; MASUI, Moriyasu; ANAN, Kosuke; HATA, Kayoko
Patent: WO2010/114181 A1, 2010 ;
Location in patent: Page/Page column 88; 89 ;
WO 2010/114181 A1
反应条件
MeTi(OiPr)3; lithium iso-propoxide; lithium iodide in tetrahydrofuran
T=20°C; 8 h;
参考文献
Wiedemann, Stefan; Frank, Daniel; Winsel, Harald; De Meijere, Armin
Organic Letters, 2003 , vol. 5, # 5 p. 753 - 755
参考文献
Eisai Co., Ltd.
Patent: EP1382603 A1, 2004 ;
Location in patent: Page 160 ;
