1-(3-氯苯基)-环丙胺合成路线 （共 3 条）
反应条件
1: With titanium(IV) isopropylate in tetrahydrofuran; diethyl ether
T=-78 - 25°C; 1.16667 h;
2: With boron trifluoride diethyl etherate in tetrahydrofuran; diethyl ether
T=25°C; 1 h;
3: With hydrogenchloride in tetrahydrofuran; diethyl ether
参考文献
NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan Andreas; SIMIC, Oliver; VULPETTI, Anna; ROGEL, Olivier
Patent: WO2012/93101 A1, 2012 ;
Location in patent: Page/Page column 261 ;
WO 2012/093101 A1
反应条件
titanium(IV) isopropylate; boron trifluoride diethyl etherate in diethyl ether
T=-70 - 20°C; 2.16667 h;
参考文献
Bertus, Philippe; Szymoniak, Jan
Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 7133 - 7136
参考文献
Eisai Co., Ltd.
Patent: EP1382603 A1, 2004 ;
Location in patent: Page 160 ;
