(S)-3-羟基哌啶 盐酸盐合成路线 (共 4 条)
反应条件
hydrogenchloride in methanol; water T=20°C; 7 h;
参考文献
Reddy, M. Somi; Narender; Rao, K. Rama
Tetrahedron, 2007 , vol. 63, # 2 p. 331 - 336
反应条件
1: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h 2: HCl / methanol; H2O / 7 h / 20 °C View Scheme
参考文献
Reddy, M. Somi; Narender; Rao, K. Rama
Tetrahedron, 2007 , vol. 63, # 2 p. 331 - 336
反应条件
1: 92 percent / Grubb's catalyst 1st generation / CH2Cl2 / 24 h / 20 °C 2: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h 3: HCl / methanol; H2O / 7 h / 20 °C View Scheme
参考文献
Reddy, M. Somi; Narender; Rao, K. Rama
Tetrahedron, 2007 , vol. 63, # 2 p. 331 - 336
反应条件
1: With formic acid in water
Heating / reflux;
2: With sodium hydroxide; water
pH=14;
参考文献
Santhera Pharmaceuticals (Schweiz) AG
Patent: EP2019100 A1, 2009 ;
Location in patent: Page/Page column 30-31 ;
EP 2019100 A1