N-[2-氯-4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N’-(5-甲基-3-异恶唑基)脲合成路线 （共 2 条）
反应条件
1: 5-methyl-isoxazol-3-ylamine; phenyl chloroformate With pyridine in N,N-dimethyl acetamide T=0 - 20°C; 2 h; 2: 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline in isobutyramide T=80°C; 5 h;
参考文献
EP1559715 A1, ;
Page/Page column 20 ;
反应条件
hydrogenchloride in water; butan-1-ol
T=20°C; Heating / reflux;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1559715 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
