(2-氧代-6-辛炔)磷酸二甲酯合成路线 （共 4 条）
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: 3-oxo-2-methylcyclohex-1-en-1-yl trifluoromethanesulfonate in tetrahydrofuran; hexane
T=-78 - 60°C; 1.33333 h; Inert atmosphere;
参考文献
Lisboa, Marilda P.; Jones, David M.; Dudley, Gregory B.
Organic Letters, 2013 , vol. 15, # 4 p. 886 - 889
反应条件
1.1: 100 percent / pyridine / CH2Cl2 / -78 - 0 °C
2.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
2.2: 21 percent / tetrahydrofuran / -78 - 60 °C
View Scheme
参考文献
Kamijo, Shin; Dudley, Gregory B.
Journal of the American Chemical Society, 2006 , vol. 128, # 19 p. 6499 - 6507
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: C11H9F9O4S in tetrahydrofuran; hexane
T=-78 - 60°C; 1.33333 h; Inert atmosphere;
参考文献
Batsomboon, Paratchata; Gold, Brian A.; Alabugin, Igor V.; Dudley, Gregory B.
Synthesis (Germany), 2012 , vol. 44, # 12 art. no. SS-2012-C0221-ST, p. 1818 - 1824
反应条件
1.1: cesium fluoride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
1.2: 18 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere
2.2: 1.33 h / -78 - 60 °C / Inert atmosphere
View Scheme
参考文献
Batsomboon, Paratchata; Gold, Brian A.; Alabugin, Igor V.; Dudley, Gregory B.
Synthesis (Germany), 2012 , vol. 44, # 12 art. no. SS-2012-C0221-ST, p. 1818 - 1824
