6-氯-2,3-二氢-5-甲氧基-1H-茚-1-酮合成路线 （共 5 条）
反应条件
1: With AlCl3, aluminium chloride in dichloromethane
T=0°C; 0.516667 h;
2: With sulfuric acid in water
T=0 - 100°C; 2.05 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/62876 A2, 2006 ;
Location in patent: Page/Page column 39-40 ;
WO 2006/062876 A2
反应条件
sodium hypochlorite; acetic acid in water
T=0 - 17°C; 3.33333 h; Large scale; regioselective reaction;
参考文献
Scott, Jeremy P.; Ashwood, Michael S.; Brands, Karel M. J.; Brewer, Sarah E.; Cowden, Cameron J.; Dolling, Uif-H.; Emerson, Khateeta M.; Gibb, Andrew D.; Goodyear, Adrian; Oliver, Steven F.; Stewart, Gavin W.; Wallace, Debra J.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 723 - 730
反应条件
1: 76 percent / pyridine; piperidine / 4 h / 80 - 115 °C
2: 72 percent / H2 / PtO2 hydrate / methanol / 6 h / 20 °C / 750.06 Torr
3: SOCl2 / 0.67 h / 60 °C
4: AlCl3 / CS2 / 1 h / 20 °C
View Scheme
参考文献
Di Stefano, Antonio; Sozio, Piera; Luisi, Grazia; Cacciatore, Ivana; Mosciatti, Barbara; Costa, Barbara; Lucacchini, Antonio; Martini, Claudia; Pinnen, Francesco
Farmaco, 2002 , vol. 57, # 4 p. 303 - 313
反应条件
1: 72 percent / H2 / PtO2 hydrate / methanol / 6 h / 20 °C / 750.06 Torr
2: SOCl2 / 0.67 h / 60 °C
3: AlCl3 / CS2 / 1 h / 20 °C
View Scheme
参考文献
Di Stefano, Antonio; Sozio, Piera; Luisi, Grazia; Cacciatore, Ivana; Mosciatti, Barbara; Costa, Barbara; Lucacchini, Antonio; Martini, Claudia; Pinnen, Francesco
Farmaco, 2002 , vol. 57, # 4 p. 303 - 313
反应条件
1: SOCl2 / 0.67 h / 60 °C
2: AlCl3 / CS2 / 1 h / 20 °C
View Scheme
参考文献
Di Stefano, Antonio; Sozio, Piera; Luisi, Grazia; Cacciatore, Ivana; Mosciatti, Barbara; Costa, Barbara; Lucacchini, Antonio; Martini, Claudia; Pinnen, Francesco
Farmaco, 2002 , vol. 57, # 4 p. 303 - 313
