3-(4-氟苯基)-5-甲基-1H-吡唑合成路线 （共 3 条）
反应条件
tetrabutylammomium bromide; toluene-4-sulfonic acid hydrazide; sodium hydroxide in water
T=80°C; 10 h; Air atmosphere;
参考文献
Wen, Jun; Fu, Yun; Zhang, Ruo-Yi; Zhang, Ji; Chen, Shan-Yong; Yu, Xiao-Qi
Tetrahedron, 2011 , vol. 67, # 49 p. 9618 - 9621
反应条件
1: morpholine*TFA / 10 h / 75 °C / Sealed vessel
2: tetrabutylammomium bromide; toluene-4-sulfonic acid hydrazide; sodium hydroxide / water / 10 h / 80 °C / Air atmosphere
View Scheme
参考文献
Wen, Jun; Fu, Yun; Zhang, Ruo-Yi; Zhang, Ji; Chen, Shan-Yong; Yu, Xiao-Qi
Tetrahedron, 2011 , vol. 67, # 49 p. 9618 - 9621
反应条件
1: cataCXium®A; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; caesium carbonate / 36 h / 60 °C / 2250.23 Torr / |Glovebox; |Inert atmosphere; |Autoclave
2: hydrazine hydrate / ethanol / 2 h / 60 °C
View Scheme
参考文献
Schranck, Johannes; Tlili, Anis; Alsabeh, Pamela G.; Neumann, Helfried; Stradiotto, Mark; Beller, Matthias
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12624 - 12628
