2-(氯甲基)-1-甲基-1H-苯并咪唑合成路线 （共 17 条）
反应条件
thionyl chloride in dichloromethane T=20°C;
参考文献
Egle, Ian; Isaac, Methvin; Urbanek, Rebecca; McLaren, Frances M.; Walsh, Sally B.; Steelman, Gary B.; Brown, Dean G.; Nugiel, David; Chen, Deborah W.; Slassi, Abdelmalik; Ma, Fupeng
Patent: US2009/192169 A1, 2009 ;
Location in patent: Page/Page column 60 ;
反应条件
1: With hydrogenchloride in water T=55°C; 2: With water; sodium hydrogencarbonate
参考文献
PLEXXIKON, INC.
Patent: WO2008/80001 A2, 2008 ;
Location in patent: Page/Page column 105-106 ;
反应条件
tetrabutylammomium bromide; potassium carbonate T=20°C; 0.133333 h;
参考文献
Dubey; Prasada Reddy; Srinivas
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 6 p. 1317 - 1322
反应条件
sodium hydroxide; chloroacetic acid in hydrogenchloride
参考文献
American Home Products Corporation
Patent: US5149700 A1, 1992 ;
反应条件
hydrogenchloride 18 h; Heating;
参考文献
Butera, John A.; Spinelli, Walter; Anantharaman, Viji; Marcopulos, Nicholas; Parsons, Roderick W.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3212 - 3228
反应条件
1: 88 percent / diisobutylaluminium hydride / hexane; tetrahydrofuran / 1 h / 0 °C 2: 255 mg / SOCl2 / CH2Cl2 / 3 h View Scheme
参考文献
RECORDATI IRELAND LIMITED; LEONARDI, Amedeo; MOTTA, Gianni; RIVA, Carlo; GUARNERI, Luciano; GRAZIANI, Davide; MARINONI, Fabio; BETTINELLI, Ilaria
Patent: WO2011/29633 A1, 2011 ;
WO 2011/029633 A1
反应条件
in dichloromethane Ambient temperature;
参考文献
Musser; Kubrak; Chang; DiZio; Hite; Hand; Lewis
Journal of medicinal chemistry, 1987 , vol. 30, # 2 p. 400 - 405
参考文献
Bai, Yu-Bin; Zhang, An-Ling; Tang, Jiang-Jiang; Gao, Jin-Ming
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 11 p. 2789 - 2795
反应条件
1: 92 percent / aq. HCl / 8 h / Heating 2: 91 percent / aq. NaOH / 0.03 h / microwave irradiation View Scheme
参考文献
Njoya, Yves; Boufatah, Narimene; Gellis, Armand; Rathelot, Pascal; Crozet, Michel P.; Vanelle, Patrice
Heterocycles, 2002 , vol. 57, # 8 p. 1423 - 1432
反应条件
1: methanol; aqueous NaOH 2: SOCl2 View Scheme
参考文献
Hughes; Lions
Journal and Proceedings of the Royal Society of New South Wales, 1937 , vol. 71, p. 209,221
