1: dimethylthiocarbamic acid S-(2-formyl-5-methoxyphenyl) ester With sodium hydroxide in methanol; water
16 h; Heating / reflux;
2: chloroacetonitrile in methanol; water
T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43904 A1, 2004 ;
Location in patent: Page 49 - 50 ;
WO 2004/043904 A1