(9CI)-6-乙氧基-4-甲基喹啉合成路线 （共 5 条）
反应条件
1: 4-ethoxy-aniline With sulfuric acid in trans-1,3-dioxane
T=0 - 100°C; Heating / reflux;
2: methyl vinyl ketone With water in trans-1,3-dioxane
3 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26871 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/026871 A1
参考文献
Mikeska
Journal of the American Chemical Society, 1920 , vol. 42, p. 2397
反应条件
hydrogenchloride; nitrobenzene
参考文献
Schering-Kahlbaum A.G.
Patent: DE518291 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2670
反应条件
Destillieren und anschliessend Erhitzen des Reaktionsprodukts mit Acetanhydrid;
参考文献
Mikeska; Haller; Adams
Journal of the American Chemical Society, 1920 , vol. 42, p. 2392
Full Text View citing articles Show Details
Palkin; Harris
J.ind.eng.Chem., 1922 , vol. 14, p. 704
Chem. Zentralbl., 1922 , vol. 93, # II p. 962
反应条件
1: 6-ethoxylepidine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: 6-methyl-pyridine-2-carboxylic acid methoxy-methyl-amide T=-78°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26871 A1, 2004 ;
Location in patent: Page 37 ;
WO 2004/026871 A1
