1-Boc-3-氰基吡咯烷合成路线 （共 8 条）
反应条件
2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide T=0°C; 2 h;
参考文献
WO2010/51245 A1, ;
Page/Page column 44 ;
WO 2010/051245 A1
反应条件
in N,N-dimethyl-formamide T=80°C; 16 h;
参考文献
US2011/166121 A1, ;
Page/Page column 43 ;
US 20110166121 A1
反应条件
manganese(IV) oxide in chloroform P=760.051 Torr; 0.25 h;
参考文献
Chemical Communications, , vol. 48, # 91 p. 11247 - 11249
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 16 h / 80 °C View Scheme
参考文献
US2011/166121 A1, ;
US 20110166121 A1
反应条件
bis(trimethylsilyl)-sulfide; sodium methylate in 1,3-dimethyl-imidazolidin-2-one; methanol T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/97691 A1, 2006 ;
Location in patent: Page/Page column 23 ;
WO 2006/097691 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane; methanol 3 h; 2: With ammonia in methanol
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; McDONALD, Edward; BLAGG, Julian; PICHOWICZ, Mark; CRUMPLER, Simon Ross
Patent: WO2010/41054 A1, 2010 ;
Location in patent: Page/Page column 36 ;
反应条件
1: tert-butyl 3-cyanopyrrolidine-1-carboxylate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=-78 - 20°C;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 63 ;
US 20110230462 A1
反应条件
1: With sodium azide; ammonium chloride in N,N-dimethyl-formamide T=120°C; 18 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; OGAWA, Anthony; OK, Hyun, O.; ONDEYKA, Debra; UJJAINWALLA, Feroze; VANDE BUNTE, Ellen
Patent: WO2010/77624 A1, 2010 ;
Location in patent: Page/Page column 49 ;
WO 2010/077624 A1
