反应条件
1: N-bromosuccinimide / CH2Cl2 / 20 °C
2: TBAB; aq. NaOH / toluene
3: aq. SnCl2 / ethanol / Heating
4: Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / 120 - 150 °C / microwave irradiation
5: KOH / methanol / Heating
View Scheme
参考文献
Beevers, Rebekah E.; Buckley, George M.; Davies, Natasha; Fraser, Joanne L.; Galvin, Francis C.; Hannah, Duncan R.; Haughan, Alan F.; Jenkins, Kerry; Mack, Stephen R.; Pitt, William R.; Ratcliffe, Andrew J.; Richard, Marianna D.; Sabin, Verity; Sharpe, Andrew; Williams, Sophie C.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2535 - 2538