4-(氯甲基)-2-苯基-1,3-噻唑合成路线 （共 21 条）
参考文献
Louvel, Julien; Guo, Dong; Agliardi, Marta; Mocking, Tamara A. M.; Kars, Roland; Pham, Tan Phat; Xia, Lizi; De Vries, Henk; Brussee, Johannes; Heitman, Laura H.; Ijzerman, Adriaan P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3213 - 3222
反应条件
sodium hydrogencarbonate
参考文献
American Home Products Corporation
Patent: US5103014 A1, 1992 ;
反应条件
1: acetone / 16 h / 20 °C 2: conc. H2SO4 / 0.75 h / 20 °C View Scheme
参考文献
Marzoni
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 2 p. 577 - 580
反应条件
1: pyridine; hydrogen sulfide; triethylamine 2: toluene / 2 h / Reflux View Scheme
参考文献
Louvel, Julien; Guo, Dong; Agliardi, Marta; Mocking, Tamara A. M.; Kars, Roland; Pham, Tan Phat; Xia, Lizi; De Vries, Henk; Brussee, Johannes; Heitman, Laura H.; Ijzerman, Adriaan P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3213 - 3222
反应条件
thionyl chloride T=65 - 70°C; 0.5 h; Yield given;
参考文献
Marzoni
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 2 p. 577 - 580
反应条件
1: aqueous NaOH 2: CrO3; H2SO4 3: SOCl2 View Scheme
参考文献
Huntress; Pfister
Journal of the American Chemical Society, 1943 , vol. 65, p. 1667,1669
反应条件
1: aqueous NaOH 2: CrO3; H2SO4 View Scheme
参考文献
Simiti; Farkas
Archiv der Pharmazie, 1974 , vol. 307, # 2 p. 81 - 88
参考文献
Suter; Johnson
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 1066
参考文献
Suter; Johnson
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 1066
反应条件
in ethyl acetate; acetonitrile
参考文献
Nissan Chemical Industries, Ltd.
Patent: US6063734 A1, 2000 ;
