3-氨基-6-(4-甲氧基苯基)哒嗪合成路线 （共 6 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol; water T=120°C; Suzuki coupling; 0.166667 h; Inert atmosphereSealed vialMicrowave irradiation;
参考文献
Gavande, Navnath; Johnston, Graham A. R.; Hanrahan, Jane R.; Chebib, Mary
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4131 - 4136
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in toluene Arylation; Suzuki coupling reaction; 5 h; Heating;
参考文献
Maes, Bert U. W.; Lemiere, Guy L. F.; Dommisse, Roger; Augustyns, Koen; Haemers, Achiel
Tetrahedron, 2000 , vol. 56, # 12 p. 1777 - 1781
反应条件
potassium hydroxide; nickel monoaluminide in methanol 2 h; Ambient temperature;
参考文献
Sitamze; Schmitt; Wermuth
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3257 - 3258
反应条件
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 2: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C 2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 3: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: in N,N-dimethyl-formamide T=80°C; Stille Cross Coupling; 5 h; 2: With potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Rahman, Mohammad Mostafizur; Akiyoshi, Yuki; Furutani, Shogo; Matsuda, Kazuhiko; Furuta, Kenjiro; Ikeda, Izumi; Ozoe, Yoshihisa
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5957 - 5964
