N-甲基-N-((3R,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-D]嘧啶-4-胺合成路线 （共 9 条）
反应条件
zinc dibromide in dichloromethane 12 h;
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1.1: 1H-imidazole / 24.5 h / 5 - 20 °C 2.1: 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium / tetrahydrofuran / 1 h / -78 °C 2.2: 2 h 3.1: n-butyllithium; hexa-methyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C 3.2: 2 h / -78 °C 4.1: magnesium / diethyl ether 4.2: 0.25 h / -20 °C 4.3: 2 h / 20 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 7.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 8.1: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1.1: 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium / tetrahydrofuran / 1 h / -78 °C 1.2: 2 h 2.1: n-butyllithium; hexa-methyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 2 h / -78 °C 3.1: magnesium / diethyl ether 3.2: 0.25 h / -20 °C 3.3: 2 h / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 6.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 7.1: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1.1: water; acetonitrile / 0.25 h / 20 °C 1.2: 1 h 2.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 3.1: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1.1: n-butyllithium; hexa-methyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 2 h / -78 °C 2.1: magnesium / diethyl ether 2.2: 0.25 h / -20 °C 2.3: 2 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 5.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 6.1: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1.1: magnesium / diethyl ether 1.2: 0.25 h / -20 °C 1.3: 2 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 4.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 5.1: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / |Inert atmosphere 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 3: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 4: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 2: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 3: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
反应条件
1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C 2: zinc dibromide / dichloromethane / 12 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 37 p. 5096 - 5098
