2-(2,5-二甲基-1H-吡咯-1-基)-5-碘吡啶合成路线 （共 6 条）
反应条件
copper(l) iodide; 1,10-phenanthroline; cesium hydrogencarbonate in toluene T=110°C; 24 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 73, # 23 p. 9326 - 9333
反应条件
1: With copper(l) iodide; sodium in N,N-dimethyl-formamide T=80°C; 3 h; 2: With ammonium chloride in di-isopropyl ether; water; N,N-dimethyl-formamide T=20°C;
参考文献
Tibotec Pharmaceuticals Ltd.
Patent: WO2007/113290 A1, 2007 ;
Location in patent: Page/Page column 40-41 ;
反应条件
copper(l) chloride in methanol; N,N-dimethyl-formamide T=80°C; Ullman methoxylation; 2 h;
参考文献
Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens
European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957
反应条件
1: 96 percent / copper(I) chloride / methanol; dimethylformamide / 2 h / 80 °C 2: 81 percent / hydroxylamine hydrochloride; triethylamine / ethanol; H2O / 20 h / Heating View Scheme
参考文献
Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens
European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957
反应条件
1.1: 96 percent / copper(I) chloride / methanol; dimethylformamide / 2 h / 80 °C 2.1: 81 percent / hydroxylamine hydrochloride; triethylamine / ethanol; H2O / 20 h / Heating 3.1: concd. HCl; aq. sodium nitrite / -5 °C 3.2: 50 percent / copper(I) chloride; concd. HCl / 0 - 70 °C View Scheme
参考文献
Luetzen, Arne; Hapke, Marko; Staats, Holger; Bunzen, Jens
European Journal of Organic Chemistry, 2003 , # 20 p. 3948 - 3957
反应条件
1: With toluene-4-sulfonic acid in toluene
5 h;
2: With sodium hydrogencarbonate in water; toluene
参考文献
Tibotec Pharmaceuticals Ltd.
Patent: WO2007/113290 A1, 2007 ;
Location in patent: Page/Page column 40-41 ;
