2-氯-4,6-二甲氧基-5-硝基嘧啶合成路线 （共 5 条）
反应条件
trifluoromethylsulfonic anhydride; NMe4NO3 in dichloromethane
T=20°C; 38 h;
参考文献
Shackelford, Scott A.; Anderson, Mark B.; Christie, Lance C.; Goetzen, Thomas; Guzman, Mark C.; Hananel, Martha A.; Kornreich, Wayne D.; Li, Haitao; Pathak, Ved P.; Rabinovich, Alex K.; Rajapakse, Ranjan J.; Truesdale, Larry K.; Tsank, Stella M.; Vazir, Haresh N.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 267 - 275
反应条件
in ethanol
T=0 - 20°C;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 33; 56-57 ;
WO 2007/000582 A1
反应条件
sodium hydride in tetrahydrofuran
T=0°C; 0.25 h;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 59 ;
WO 2007/000582 A1
反应条件
1: sodium hydride / tetrahydrofuran / -41 °C
2: iron; ammonium chloride / ethanol
View Scheme
参考文献
Olberg, Dag Erlend; Andressen, Kjetil Wessel; Levy, Finn Olav; Klaveness, Jo; Haraldsen, Ira; Sutcliffe, Julie L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1846 - 1850
反应条件
triethylamine in ethanol
T=0 - 20°C;
参考文献
PARADIGM THERAPEUTICS LTD.
Patent: WO2007/582 A1, 2007 ;
Location in patent: Page/Page column 39; 87-88 ;
WO 2007/000582 A1
