formic acid in water T=10 - 40°C; 3 h; Product distribution / selectivity;

hydrogenchloride in chloroform; water; acetone

1: 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidin-3-carbonitrile With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane 2 h; Inert atmosphereSealed tube; 2: N-ethyI-N-(3-(4,4,5,5-tetramethyI-1,3,2-dioxaboroIan-2-yl)phenyI)acetamide With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane; water T=20°C; Sealed tube;

1: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide With sodium hydride in N,N-dimethyl-formamide T=20°C; 1 h; 2: ethyl iodide in N,N-dimethyl-formamide T=20°C; 24 h;

hydrogenchloride in ethanol; water