噻吩并[3,2-b]吡啶-2-羧酸甲酯合成路线 （共 4 条）
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Groppi JR., Vincent E.
Patent: US2003/45540 A1, 2003 ;
反应条件
sodium hydroxide; sodium nitrite in water; hypophosphorous ether
参考文献
Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Groppi JR., Vincent E.
Patent: US2003/45540 A1, 2003 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide; water / 3 h / 40 °C
2: hypophosphorous ether; sodium nitrite / water / 3 h / Cooling with ice bath
View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: WO2011/79804 A1, 2011 ;
WO 2011/079804 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 0.833333 h;
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
Location in patent: Page/Page column 14 ;
US 20120245178 A1
