4,5-二氢-3-(4-羟基苯基)-5-异恶唑乙酸甲酯合成路线 （共 12 条）
反应条件
potassium fluoride; 18-crown-6 ether in dichloromethane; water
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
copper dichloride; palladium dichloride
P=760 Torr;
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
2: KF; 18-crown-6 / CH2Cl2; H2O
3: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: PCC; NaOAc; MgSO4 / CH2Cl2
2: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
3: KF; 18-crown-6 / CH2Cl2; H2O
4: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: KF; 18-crown-6 / CH2Cl2; H2O
2: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: tetrahydrofuran / 20 °C
2: PCC; NaOAc; MgSO4 / CH2Cl2
3: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
4: KF; 18-crown-6 / CH2Cl2; H2O
5: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
2: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: PCC; NaOAc; MgSO4 / CH2Cl2
2: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
3: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: tetrahydrofuran / 20 °C
2: PCC; NaOAc; MgSO4 / CH2Cl2
3: NH2OH*HCl; NaOAc / ethanol; H2O / Heating
4: 21 percent / CuCl2 / PdCl2 / 760 Torr
View Scheme
参考文献
Mosher, Michael D.; Emmerich, Laura G.; Frost, Katherine S.; Anderson, Benjamin
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 535 - 539
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 5 h / 20 °C
2: triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere
3: chloro-trimethyl-silane
View Scheme
参考文献
Alam, Athar; Pal, Chinmay; Goyal, Manish; Kundu, Milan Kumar; Kumar, Rahul; Iqbal, Mohd Shameel; Dey, Sumanta; Bindu, Samik; Sarkar, Souvik; Pal, Uttam; Maiti, Nakul C.; Adhikari, Susanta; Bandyopadhyay, Uday
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7365 - 7373
