4-[5-[[(3-碘苯基)甲基]硫基]-1,3,4-恶二唑-2-基]吡啶合成路线 （共 6 条）
反应条件
sodium hydroxide in N,N-dimethyl-formamide
T=20°C; 5 h; Inert atmosphere;
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Narum, Lars; Norskov-Lauritsen, Leif; Olesen, Preben H.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 11 p. 1525 - 1528
反应条件
1: triethylamine / ethanol / Reflux; Inert atmosphere
2: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424
反应条件
1: 0 - 50 °C
2: hydrazine hydrate / ethanol / Reflux
3: triethylamine / ethanol / Reflux; Inert atmosphere
4: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424
反应条件
1: hydrazine hydrate / ethanol / Reflux
2: triethylamine / ethanol / Reflux; Inert atmosphere
3: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Anumala, Upendra Rao; Marinelli, Luciana; La Pietra, Valeria; Novellino, Ettore; Franco, Benedicte; Demedts, David; Van Leuven, Fred; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4407 - 4424
反应条件
1: hydrazine hydrate / ethanol / 1 h / 60 °C
2: potassium hydroxide / ethanol / 18 h / 60 °C
3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
View Scheme
参考文献
Lukas, Thomas J.; Schiltz, Gary E.; Arrat, Hasan; Scheidt, Karl; Siddique, Teepu
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1532 - 1537
