1: (E,Z)-crotononitrile With hydrazine in tetrahydrofuran; water
T=0 - 20°C; 2.33 h;
2: 4-methoxy-benzaldehyde in tetrahydrofuran; water
T=20°C; 3.25 h;
3: With sodium n-butanolate in butan-1-ol
T=25 - 120°C; 3.33 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Patent: WO2009/62308 A1, 2009 ;
Location in patent: Page/Page column 56-58 ;