4-羟基氮杂环庚烷-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1: 1-benzyl-4-hydroxyhexahydro-1H-azepine With ammonium formate; palladium 10 on activated carbon in ethanol 1 h; Heating / reflux; 2: carbonic acid di-tert-butyl ester in dichloromethane T=20°C; 19 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 93-94 ;
EP 1403255 A1
反应条件
lithium borohydride in tetrahydrofuran T=0°C; 1 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 30 ;
反应条件
in dichloromethane T=20°C; 19 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 48 ;
EP 1500643 A1
反应条件
1: 20 palladium(II) hydroxide on carbon; triethylamine; hydrogen / ethyl acetate / 20 °C 2: sodium tetrahydroborate / methanol / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
JANSSEN RandD IRELAND; GUILLEMONT, Jerôme, Emile, Georges; LANÇOIS, David, Francis, Alain; MOTTE, Magali, Madeleine, Simone; KOUL, Anil; BALEMANS, Wendy, Mia, Albert
Patent: WO2013/21051 A1, 2013 ;
WO 2013/021051 A1
反应条件
hydrogenchloride in ethyl acetate T=20°C; 5 h;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi
Patent: WO2011/19090 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/019090 A1
反应条件
sulfur trioxide pyridine complex; triethylamine in dimethyl sulfoxide T=20°C; 3.5 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 48 ;
EP 1500643 A1
